Viruses, Vol. 15, Pages 1620: The First Case of Zika Virus Disease in Guinea: Description, Virus Isolation, Sequencing, and Seroprevalence in Local Population

Viruses, Vol. 15, Pages 1620: The First Case of Zika Virus Disease in Guinea: Description, Virus Isolation, Sequencing, and Seroprevalence in Local Population Viruses doi: 10.3390/v15081620 Authors: Roman B. Bayandin Marat T. Makenov Sanaba Boumbaly Olga A. Stukolova Anastasia V. Gladysheva Andrey V. Shipovalov Maksim O. Skarnovich Ousmane Camara Aboubacar Hady Toure Victor A. Svyatchenko Alexander N. Shvalov Vladimir A. Ternovoi Mamadou Y. Boiro Alexander P. Agafonov Lyudmila S. Karan The Zika virus (ZIKV) is a widespread mosquito-borne pathogen. Phylogenetically, two lineages of ZIKV are distinguished: African and Asian–American. The latter became the cause of the 2015–2016 pandemic, with severe consequences for newborns. In West African countries, the African lineage was found, but there is evidence of the emergence of the Asian–American lineage in Cape Verde and Angola. This highlights the need to not only monitor ZIKV but also sequence the isolates. In this article, we present a case report of Zika fever in a pregnant woman from Guinea identified in 2018. Viral RNA was detected through qRT-PCR in a serum sample. In addition, the seroconversion of anti-Zika IgM and IgG antibodies was detected in repeated blood samples. Subsequently, the virus was isolated from the C6/36 cell line. The detected ZIKV belonged to the African lineage, the Nigerian sublineage. The strains with the closest sequences w...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research