A Multi-epitope Vaccine Candidate Against Bolivian Hemorrhagic fever Caused by Machupo Virus

In this study, GPC protein was considered to design a multi-epitope, multivalent vaccine containing antigenic and immunogenic CTL and HTL epitopes. Different structural validations and physicochemical properties were analysed to validate the vaccine. Docking and molecular dynamics simulations were conducted to understand the interactions of the vaccine with various immune receptors. Finally, the vaccine was codon optimised in silico and along with which immune simulation studies was performed in order to evaluate the vaccine's effectiveness in triggering an efficacious immune response against MACV.PMID:37479961 | DOI:10.1007/s12010-023-04604-9

Source: Applied Biochemistry and Biotechnology - July 21, 2023 Category: Biochemistry Authors: Zeeshan Ali Jyothsna Volisha Cardoza Srijita Basak Utkarsh Narsaria Surjit Bhattacharjee Unnati Meher G Samuel Paul Isaac Tanos C C Franca Steven R LaPlante Sudhan S George Source Type: research