Molecules, Vol. 28, Pages 5587: Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

Molecules, Vol. 28, Pages 5587: Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer Molecules doi: 10.3390/molecules28145587 Authors: Ingryd Nayara de Farias Ramos Monique Feitosa da Silva Jefferson Marcio Sanches Lopes Jordy Neves Cruz Fabrine Silva Alves José de Arimatéia Rodrigues do Rego Marcondes Lima da Costa Paulo Pimentel de Assumpção Davi do Socorro Barros Brasil André Salim Khayat Gastric cancer is one of the most frequent types of neoplasms worldwide, usually presenting as aggressive and difficult-to-manage tumors. The search for new structures with anticancer potential encompasses a vast research field in which natural products arise as promising alternatives. In this scenario, piperine, an alkaloid of the Piper species, has received attention due to its biological activity, including anticancer attributes. The present work proposes three heating-independent, reliable, low-cost, and selective methods for obtaining piperine from Piper nigrum L. (Black pepper). Electronic (SEM) and optical microscopies, X-ray diffraction, nuclear magnetic resonance spectroscopies (13C and 1H NMR), and optical spectroscopies (UV–Vis, photoluminescence, and FTIR) confirm the obtention of piperine crystals. The MTT assay reveals that the piperine samples exhibit good cytotoxic activity against primary and metastasis models of ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research