MicroRNA biogenesis machinery activation and lncRNA and REST overexpression as neuroprotective responses to fight inflammation in the hippocampus

Brain Long non-coding RNA (lncRNA) and microRNAs (miRs) play essential roles in the regulation of several important biological processes, including neuronal activity, cognitive processes, neurogenesis, angiogenesis, and neuroinflammation. In this context, the transcriptional repressor, RE1 silencing transcription factor (Rest), acts regulating the expression of neuronal genes as well as of lncRNAs and multiple miRNAs in the central nervous system. Nevertheless, its role in neuroinflammation was less explored.

Source: Journal of Neuroimmunology - July 18, 2023 Category: Allergy & Immunology Authors: Liebert Bernardes Carvalho, Paula Lemes dos Santos Sanna, Camila Cristina dos Santos Afonso, Eduardo F. Bondan, Ge órgia da Silva Feltran, Marcel Rodrigues Ferreira, Alexander Birbrair, Denise Carleto Andia, Alexandra Latini, Rodrigo A. Foganholi da Silv Source Type: research