Pharmacokinetics of Commonly Used Antimicrobials in Critically Ill Pediatric Patients During Extracorporeal Membrane Oxygenation: A Systematic Review

CONCLUSION: Limited data exists on the PK/PD of antimicrobials during ECMO therapy in the pediatric population. Rigorously designed population PK studies are required to establish empiric dosing guidelines for antimicrobials in patients requiring this therapeutic modality. The use of therapeutic drug monitoring for antimicrobials in pediatric patients on ECMO should be encouraged to optimize dosing.TRIAL REGISTRY: PROSPERO registration number: CRD42018099992 (Registered: July 24th 2018).PMID:37450191 | DOI:10.1007/s40272-023-00582-x

Source: Paediatric Drugs - July 14, 2023 Category: Pediatrics Authors: Marc-Alexandre Duceppe Salmaan Kanji Anh Thu Do Ni Ruo Yiorgos Alexandros Cavayas Martin Albert Maxime Robert-Halabi Samara Zavalkoff Laura Benichou Gordan Samoukovic David R Williamson Source Type: research