CDN1163, a SERCA activator, causes intracellular Ca < sup > 2+ < /sup > leak, mitochondrial hyperpolarization and cell cycle arrest in mouse neuronal N2A cells

CONCLUSION: CDN1163 caused internal Ca2+ leak, cytosolic Ca2+ overload, mitochondrial Ca2+ elevation and hyperpolarization, cell cycle arrest and cell growth inhibition.PMID:37429421 | DOI:10.1016/j.neuro.2023.07.001

Source: Neurotoxicology - July 10, 2023 Category: Neurology Authors: Yi-Ping Huang Wen-Wei Huang Kun-Feng Tsai Lian-Ru Shiao Zih-He Yang Shao-Yun Tseng Yu-Hsien Lin Cing-Yu Chen Paul Chan Yuk-Man Leung Source Type: research