Global Burden of Transfusion in Sickle Cell Disease

Sickle cell disease (SCD) is the most common hereditary hemoglobinopathy. The underlying pathophysiology of the red blood cell (RBC) leads to pan-systemic complications which manifest at an early age. While curative and disease-modifying treatments exist for SCD, a key intervention in the management and treatment of SCD is RBC transfusion, which can alleviate or prevent many complications. SCD patients often require chronic RBC transfusion therapy which can result in complications, such as iron overload, alloimmunization and infection.

Source: Transfusion and Apheresis Science - July 17, 2023 Category: Hematology Authors: Baba PD Inusa, Wale Atoyebi, Biree Andemariam, James N Hourani, Laurel Omert Source Type: research