Predictors of COVID ‑19‑associated mortality among hospitalized elderly patients with dementia

Exp Ther Med. 2023 Jul 3;26(2):395. doi: 10.3892/etm.2023.12094. eCollection 2023 Aug.ABSTRACTThe mortality of elderly patients with dementia hospitalized with coronavirus disease 2019 (COVID-19)-associated pneumonia is high. The mortality rate of these patients continues to be high following their discharge. However, data on the outcomes of these patients in all phases of the pandemic are limited. The aim of the present study was to examine the clinical characteristics and the in-hospital and 90-day mortality rates of elderly patients with dementia hospitalized due to COVID-19-associated pneumonia during all phases of the pandemic. During the time period between February 15, 2021 to July 15, 2022, 105 elderly patients (≥65 years old) with dementia of various etiologies were hospitalized due to COVID-19-associated pneumonia. The patient characteristics and in-hospital outcomes within 90 days of admission were recorded. The mean age of the patients was 84.03±7.61 years and 60 (57.1%) patients were females. A total of 52 (49.5%) patients were hospitalized during the omicron variant period, 27 (25.7%) were fully vaccinated (three doses) and 38 (36.2%) patients succumbed during their hospitalization. In total, 52 (49.5%) patients succumbed within the first 90 days of admission. According to the univariate regression analysis, the omicron variant [hazard ratio (HR), 2.126; 95% confidence interval (CI), 1.073-4.213; P=0.031] and the absence of full vaccination (HR, 6.231; 95% CI...

Source: Experimental and Therapeutic Medicine - July 17, 2023 Category: General Medicine Authors: Vasiliki Epameinondas Georgakopoulou Aikaterini Gkoufa Aristeidis Tsakanikas Sotiria Makrodimitri Georgios Karamanakos Dimitrios Basoulis Pantazis M Voutsinas Irene Eliadi Anastasia Bougea Demetrios A Spandidos Efthalia Angelopoulou Paschalis Steiropoulos Source Type: research