CIC inactivating mutations identify aggressive subset of 1p19q codeleted gliomas

Conclusion. CIC mutations result in protein inactivation with up‐regulation of CIC target genes, activation of proliferative pathways, inhibition of differentiation, and poorer outcome in patients with a 1p19q codeleted gliomas. This article is protected by copyright. All rights reserved.

Source: Annals of Neurology - May 27, 2015 Category: Neurology Authors: Vincent Gleize, Agusti Alentorn, Léa Connen de Kérillis, Marianne Labussière, Aravidan Nadaradjane, Emeline Mundwiller, Chris Ottolenghi, Stephanie Mangesius, Amithys Rahimian, François Ducray, on behalf of the POLA network, Karima Mokhtari, Chiara Vi Tags: Research Article Source Type: research