Mandibular primary intraosseous carcinoma arising from long standing odontogenic keratocyst

Primary intraosseous carcinoma (PIOC) of the jaw is a rare neoplasm which can arise either from the lining epithelium of odontogenic cysts or "de novo" from odontogenic epithelial rests. When the odontogenic cyst is present in the jaws for a long time, the stratified squamous epithelium can become malignant due to chronic inflammation. To be classified as PIOC, the lesion must not have any communication with the surrounding mucosa of the upper aerodigestive tract. Sometimes, it becomes difficult to differentiate PIOC from true carcinoma that originated from the oral mucosa.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Case Report Source Type: research