Schwann cell ‐derived amphiregulin enhances nerve regeneration via supporting the proliferation and migration of Schwann cells and the elongation of axons

Peripheral nerve injury induces the elevation of growth factor amphiregulin (AREG) expression in Schwann cells. Up-regulated AREG supports the proliferation and migration of Schwann cells by activating ERK1/2 cascade, benefits the outgrowth of neurites and the elongation of injured axons, and thus may contribute to peripheral nerve repair and regeneration. Our results thus identify AREG as a promising therapeutic avenue towards peripheral nerve injury. AbstractPeripheral nerves have limited regeneration ability following nerve injury. Applying growth factors with neurotrophic roles is beneficial for accelerating peripheral nerve regeneration. Here we show that after rat sciatic nerve injury, growth factor amphiregulin (AREG) is upregulated in Schwann cells of sciatic nerves. Elevated AREG stimulates the proliferation and migration of Schwann cells by activating ERK1/2 cascade. Schwann cell-secreted AREG further facilitates the outgrowth of neurites and the elongation of injured axons. Administration of AREG to injured sciatic nerves stimulates the proliferation of Schwann cells to replace lost cell population, encourages the migration of Schwann cells to form cell cords, and facilitates the regrowth of axons. Overall, our results identify AREG as an important neurotrophic factor and thus provide a promising therapeutic avenue towards peripheral nerve injury.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research