Exploration of complement split products in plasma and urine as biomarkers of kidney graft rejection

CONCLUSION: This study shows increased plasma C3a and C3dg in kidney transplant recipients, primarily with T cell mediated rejection. This finding suggests that consecutive measurements of C3a and C3dg in plasma could be applicable to monitor alloreactivity in kidney transplant recipients. Urine complement split products are unsuitable as rejection biomarkers since the permeability of the glomerular filtration barrier strongly influences them. Prospective longitudinal studies on plasma C3a and C3dg dynamics will be needed to validate present findings.PMID:37406469 | DOI:10.1016/j.imbio.2023.152462
Source: Immunobiology - Category: Allergy & Immunology Authors: Source Type: research