Bone-Derived IGF-I Regulates Radial Bone Growth in Adult Male mice

In conclusion, inactivation of IGF-I in cortical bone with unchanged liver-derived IGF-I in older male mice resulted in reduced radial growth of cortical bone. This suggests that not only circulating IGF-I, but also locally derived IGF-I, regulates the cortical bone phenotype in older mice.PMID:37406213 | DOI:10.1210/endocr/bqad104

Source: Endocrinology - July 5, 2023 Category: Endocrinology Authors: Johan Svensson Klara Sj ögren Lina Lawenius Antti Koskela Juha Tuukkanen Karin H Nilsson Sofia Mov érare-Skrtic Claes Ohlsson Source Type: research