Voxel-Based Dosimetry Predicts Hepatotoxicity in Hepatocellular Carcinoma Patients Undergoing Radioembolization with 90Y Glass Microspheres

Conclusion: Voxel-based dosimetry may more accurately predict hepatotoxicity than multicompartment dosimetry in HCC patients undergoing radioembolization, which could enable dose escalation or deescalation with the intent to optimize treatment response. Our results indicate that a V40 of 72% may be particularly useful in whole-liver treatment. However, further research is warranted to validate these results.

Source: Journal of Nuclear Medicine - June 30, 2023 Category: Nuclear Medicine Authors: Watanabe, M., Grafe, H., Theysohn, J., Schaarschmidt, B., Ludwig, J., Jochheim, L., Jeschke, M., Schmidt, H., Fendler, W. P., Moraitis, A., Herrmann, K., Pomykala, K. L., Weber, M. Tags: Clinical Investigations Source Type: research