Nucleocapsid-Specific Antibodies as a Correlate of Protection against SARS-CoV-2 Reinfection in Children

SARS-CoV-2 infection confers relative protection against reinfection, albeit short-term and incomplete,1 and improved immune correlates and vaccine approaches are required to reduce the prevalence of reinfection. Spike-specific antibody titres associate with protection in adults2 whilst both infection3 and vaccination were protective in children during the initial phases of the pandemic.4 However, the omicron variant shows increased infectivity and protection afforded by ancestral-spike based vaccines has diminished markedly.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research