Viral co-infection, autoimmunity, and CSF HIV antibody profiles in HIV central nervous system escape

Antiretroviral therapy (ART) suppresses plasma and cerebrospinal fluid (CSF) HIV replication. Neurosymptomatic (NS) CSF escape is a rare exception in which CNS HIV replication occurs in the setting of neurologic impairment. The origins of NS escape are not fully understood. We performed a case-control study of asymptomatic (AS) escape and NS escape subjects with HIV-negative subjects as controls in which we investigated differential immunoreactivity to self-antigens in the CSF of NS escape by employing neuroanatomic CSF immunostaining and massively multiplexed self-antigen serology (PhIP-Seq).

Source: Journal of Neuroimmunology - June 28, 2023 Category: Allergy & Immunology Authors: I.A. Hawes, B.D. Alvarenga, W. Browne, A. Wapniarski, R. Dandekar, C.M. Bartley, G.M. Sowa, J.L. DeRisi, P. Cinque, A.N. Dravid, S.J. Pleasure, M. Gisslen, R.W. Price, M.R. Wilson Source Type: research