Intrathecal CD8+CD20+ T Cells in Primary Progressive Multiple Sclerosis

This study shows an association between intrathecal CD8+CD20+ T cells, white matter injury, and thalamic atrophy in PPMS, suggesting a role of CD8+CD20+ T cells in the immunopathogenesis of PPMS. The results also suggest that limited efficacy of dimethyl fumarate in PPMS may, at least partly, be a consequence of failure to suppress CD8+CD20+ T cells in CSF.

Source: Neurology Neuroimmunology and Neuroinflammation - June 27, 2023 Category: Neurology Authors: von Essen, M. R., Talbot, J., Hansen, R. H. H., Chow, H. H., Lundell, H., Siebner, H. R., Sellebjerg, F. Tags: Cerebrospinal Fluid, Multiple sclerosis Research Article Source Type: research