Filamentous Fungi-Derived Orsellinic Acid-Sesquiterpene Meroterpenoids: Fungal Sources, Chemical Structures, Bioactivities, and Biosynthesis
Planta Med DOI: 10.1055/a-2099-4932Fungi-derived polyketide-terpenoid hybrids are important meroterpenoid natural products that possess diverse structure scaffolds with a broad spectrum of bioactivities. Herein, we focus on
an ever-increasing group of meroterpenoids, orsellinic acid-sesquiterpene hybrids comprised of biosynthetic start unit orsellinic acid coupling to a farnesyl group or/and its modified cyclic
products. The review entails the search of China National Knowledge Infrastructure (CNKI), Web of Science, Science Direct, Google Scholar, and PubMed databases up to June 2022. The key terms
include “orsellinic acid”, “sesquiterpene”, “ascochlorin”, “ascofuranone”, and “Ascochyta viciae”, which are combined with the structures of “ascochlorin” and “ascofuranone” drawn by
the Reaxys and Scifinder databases. In our search, these orsellinic acid-sesquiterpene hybrids are mainly produced by filamentous fungi. Ascochlorin was the first compound reported in 1968
and isolated from filamentous fungus Ascochyta viciae (synonym: Acremonium egyptiacum; Acremonium sclerotigenum); to date, 71 molecules are discovered from various filamentous
fungi inhabiting in a variety of ecological niches. As typical representatives of the hybrid molecules, the biosynthetic pathway of ascofuranone and ascochlorin are discussed. The group of
meroterpenoid hybrids exhibits a broad arrange of bioactivities, as highlighted by targeting h...
Source: Planta Medica - Category: Drugs & Pharmacology Authors: Gao, Hua Zhou, Luning Zhang, Peng Wang, Ying Qian, Xuan Liu, Yujia Wu, Guangwei Tags: Reviews Source Type: research