Adrenal gland response to adrenocorticotropic hormone is intact in patients with postural orthostatic tachycardia syndrome

Many patients with postural orthostatic tachycardia syndrome (POTS) are hypovolemic with plasma volume deficits of 10 –30 %. Some also have low levels of aldosterone and diminished aldosterone-renin ratios despite elevations in angiotensin II, pointing to potential adrenal dysfunction. To assess adrenal gland responsiveness in POTS, we measured circulating levels of aldosterone and cortisol following adrenocort icotropin hormone (ACTH) stimulation.

Source: Autonomic Neuroscience: Basic and Clinical - June 23, 2023 Category: Neuroscience Authors: Jill K.H. Laurin, Oyebimbola A. Oyewunmi, Emily M. Garland, Alfredo Gamboa, Victor C. Nwazue, Sachin Y. Paranjape, Bonnie K. Black, Luis E. Okamoto, Cyndya A. Shibao, Italo Biaggioni, David Robertson, Andr é Diedrich, William D. Dupont, Robert S. Sheldon Source Type: research