Summer Fun Shadowed by Deadly Skin Cancer

It's not surprising that May signifies both the official kickoff to summer and Skin Cancer Awareness month. It's a great reminder to protect your skin while enjoying the beautiful outdoors. Whether it's a day at the pool, a barbecue with friends or simply driving in the car, protecting your skin from the harmful effects of the sun is important not only during the summer, but all year long. According to www.skincancer.org, an estimated 2.8 million cases of basal cell carcinoma (BCC), the most common form of skin cancer, were diagnosed in the U.S. in 2010. That figure continues to climb. Dr. Anna Garrett was diagnosed with basal cell cancer on a routine "get to know you" visit to a new dermatologist in the city she had just moved to. Anna says, "The doctor was examining my face with her magnifying glass and came across a small spot (that looked like others on my face) and asked, 'How long has that been there?' I answered I did not know." One biopsy later, Anna found out it was malignant. She was not new to skin cancer. Anna had a long family history of melanoma that included the loss of both her dad and uncle. Fortunately, Anna had Mohs surgery, and it was taken care of. Now, she's vigilant about visiting her dermatologist for ANYTHING that looks off! Liz Toombs says, "I had bad tanning practices and a lot of moles. At the urging of my mom and husband, I had them checked out." Liz was 25 when the physician assistant at the dermatolog...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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The objective of this study will be to systematically evaluate observational data that present incidence of incomplete surgical excision amongst adult patients with non-melanoma skin cancer worldwide.MethodsWe designed and registered a study protocol for a systematic review and meta-analysis of descriptive epidemiology data. A comprehensive literature search will be conducted (from January 2000 onwards) in MEDLINE, EMBASE, Scopus, CINAHL, EMCare and Cochrane Library. Grey literature will be identified through searching Open Grey, dissertation databases (e.g. Open Access Theses and Dissertations) and clinical trial register...
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Cutaneous melanoma, also called malignant melanoma, is the type of skin cancer that is most likely to spread to other parts of the body. Though melanoma accounts for only about 1% of skin cancers, it is responsible for more than 90% of skin cancer-related deaths. But thanks to developments in skin cancer treatment (mostly in the last decade), patients with melanoma have much better chances of living longer. What is a melanoma? Melanoma involves the uncontrolled growth of a type of cell known as a melanocyte. One of the most important functions of a normal melanocyte is to protect your skin from the sun’s damaging ult...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Skin and Hair Care Source Type: blogs
CONCLUSION: SCF has a great role in skin hyperpigmented disorders and this can be used as a target for the developing of new antipigmentary lines of treatment by inhibiting SCF. SCF can also be involved in the emergence of some skin tumors. PMID: 31870114 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer after basal cell carcinoma. While most cases are cured by excision, a substantial number of patients will develop local, regional, or distant recurrences, with the number of cSCC-related deaths approaching that from melanoma. Several clinical decisions, including the extent of surgical margins, the use of adjuvant radiation or chemotherapy, and sentinel lymph node biopsy/completion dissection, could be informed by a patient ’s relative risk of recurrence.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Santosh K. Ghosh1*, Thomas S. McCormick1,2 and Aaron Weinberg1* 1Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, United States 2Dermatology, School of Medicine, Case Western Reserve University, Cleveland, OH, United States Human beta-defensins (hBDs, −1, 2, 3) are a family of epithelial cell derived antimicrobial peptides (AMPs) that protect mucosal membranes from microbial challenges. In addition to their antimicrobial activities, they possess other functions; e.g., cell activation, proliferation, regulation of cytokine/chemokine production, migration, diffe...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
We present a case of diagnosed xeroderma pigmentosum in a 25 year old male who presented with multiple lesions and non-healing ulcers on face. Four surgical specimens from left lower eyelid, chin, right cheek and upper lip were taken for histopathological diagnosis. Microscopic examination revealed five different tumors from biopsies of these sites - specimen from right cheek revealed two morphologically distinct tumors. The tumors include basosquamous carcinoma, nodular basal cell carcinoma, adenoid basal cell carcinoma, malignant melanoma and cavernous hemangioma. PMID: 30992739 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Basal cell carcinoma (BCC) often appears on the face and neck and recurrence rates are significant. Our patented skin Micobiopsy is a minimally invasive device that does not require local anaesthetic nor sutures. The aims of this study were to evaluate 1) feasibility of microbiopsy sampling in suspected BCC lesions; 2) evaluate sample quality for Real-Time PCR biomarker analysis; and 3) compare BCC mRNA biomarker expression levels to conventional shave biopsy. We collected 1,170 microbiopsy samples from 106 patients with suspected BCC lesions.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research
CONCLUSION: Our findings confirm that superficial radiotherapy is an effective treatment for early BCC or SCC of the vermilion lip, especially in the ageing population, in high-risk tumours, and even if poor cosmetic outcome is expected from surgical excision. PMID: 30973789 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Skin cancer can be broadly categorized into melanoma and nonmelanoma skin cancer (NMSC). Squamous cell carcinoma and basal cell carcinoma are the most common subtypes of NMSC. When a patient presents with a skin finding suspect for NMSC, a confirming skin biopsy is performed. On the basis of the biopsy results, patient factors, and clinical characteristics of the cancer, an appropriate form of treatment is selected. Mohs micrographic surgery (or Mohs) is a tissue-sparing surgical approach, utilizing frozen section margin control. Once removal of the NMSC has been assured by Mohs surgery, the resultant skin defect is evalua...
Source: JDNA: Journal of the Dermatology Nurses Association - Category: Dermatology Tags: FEATURE ARTICLES Source Type: research
Conclusion: Vibrational spectroscopy highlighted increased glycosylation in melanoma.
Source: In Vivo - Category: Research Authors: Tags: Clinical Studies Source Type: research
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