Neutralizing antibody levels and epidemiological information of patients with breakthrough COVID-19 infection in Toyama, Japan

In this study, we analyzed the epidemiological information and possession status of neutralizing antibodies in patients with BI using SARS-CoV-2 pseudotyped viruses (SARS-CoV-2pv). Analysis of 44 specimens diagnosed with COVID-19 after two or more vaccinations showed high inhibition of infection by 90% or more against the Wuhan strain and the Alpha and Delta variants of pseudotyped viruses in 40 specimens. In contrast, almost no neutralizing activity was observed against the Omicron BA.1 variant. Many cases without neutralizing activity or BI were immunosuppressed individuals. The results of this study show that contact with an infected person can result in BI even when there are sufficient neutralizing antibodies in the blood. Thus, even after vaccination, sufficient precautions must be taken to prevent infection.PMID:37258174 | DOI:10.7883/yoken.JJID.2023.100

Source: Japanese Journal of Infectious Diseases - May 31, 2023 Category: Infectious Diseases Authors: Hideki Tani Noriko Inasaki Shunsuke Yazawa Takahisa Shimada Yumiko Saga Hiroyasu Kaya Yumiko Maruyama Sadaya Matano Hiroyuki Itoh Tatsuhiko Kashii Emiko Yamazaki Masae Itamochi Kazunori Oishi Source Type: research