Competition between p53 and YY1 determines PHGDH expression and malignancy in bladder cancer

ConclusionYY1 drives PHGDH expression in the context of mutant p53 and promotes bladder tumorigenesis, which preliminarily explains the relationship between high-frequency mutations of p53 and dysfunctional serine metabolism in bladder cancer.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research