Exercise and arrhythmogenic cardiomyopathy: all things in moderation

Since right ventricular (RV) dysplasia was described in an autopsy case series of young adults with sudden cardiac death (SCD) in the early 1980s,1 researchers have sought to unravel the complex relationship between exercise and SCD in arrhythmogenic right ventricular cardiomyopathy (ARVC). Advanced cardiac imaging and genetic testing have since enriched our understanding of how pathogenic variants in an expanding array of genes manifest cardiomyopathy of either ventricle and a propensity toward ventricular arrythmia. The more inclusive term arrhythmogenic cardiomyopathy (ACM) was created to recognise the potential for left ventricular (LV), RV or biventricular involvement. However, while the initial reports of ARVC lacked the phenotyping and genotyping that are commonplace today, they did report on the close association between physical exertion and ventricular arrhythmias, as 10 of the 60 initially described patients had died during exertion.1 Subsequent studies have provided more granular definitions of athletics...
Source: Heart - Category: Cardiology Authors: Tags: Editorials Source Type: research