Neuroendocrinology of menopause: the symptoms, the risks and the management

The transition into menopause has long been related to the development of climacteric symptoms, with hot flashes and night sweats being the most commonly reported. Evidence retrieved from rat studies has highlighted the role of hypothalamic neurons expressing neurokinin B, kisspeptin, and dynorphin (KNDy neurons), in the origin of vasomotor symptoms. Kisspeptin represents a group of potent neuropeptides known to regulate the human reproductive system. The KNDy neurons are projected to the heat dissipation neurons and the gonadotropin-releasing hormone neurons.
Source: Maturitas - Category: Primary Care Authors: Tags: Abstract ID: 232 Source Type: research