Morphological and molecular comparison of HIV-associated and sporadic inclusion body myositis

ConclusionDespite HIV-IBM and sIBM sharing important clinical, histopathological, and transcriptomic signatures, the presence of KLRG1+ cells discriminated sIBM from HIV-IBM. This may be explained by longer disease duration and subsequent T-cell stimulation in sIBM. Thus, the presence of TEMRA cells is characteristic for sIBM, but not a prerequisite for the development of IBM in HIV+ patients.
Source: Journal of Neurology - Category: Neurology Source Type: research