GI highlights from the literature

Basic scienceGood-sleep diet: effects on sleep mediated by gut-to-brain direct interactions in modified diets Titos I, Juginović A, Vaccaro A, et al. A gut-secreted peptide suppresses arousability from sleep. Cell 2023;1867:1382–1397.e21. doi: 10.1016/j.cell.2023.02.022. To ensure sleep is deep and restorative, external stimuli have to be suppressed. Across species, ‘good sleep’ is influenced by multiple genes. External factors, like diet, have been recognised to impact on sleep quality. Titos et al identified a gut signalling pathway that suppresses arousability in flies and mice models. Using increased vibrations’ intensity, Titos et al identified arousable phenotypes of flies. Neuropeptide CCHamide1 (CCHa1) and its receptor were then recognised as leading to hyperarousability and poor sleep when suppressed. Depletion of CCHa1, which is present in the nervous system and enteroendocrine cells, in the gut alone was enough to increase arousability (but not other aspects of sleep). By activating enteroendocrine cells, the authors...

Source: Gut - June 7, 2023 Category: Gastroenterology Authors: Smith, P. J. Tags: Gut JournalScan Source Type: research