Transplacental delivery of therapeutic proteins by engineered IgG: a step towards perinatal replacement therapy

CONCLUSIONS: Our results pave the way towards the development of novel strategies for the in utero delivery of endogenous maternal proteins to replace genetically deficient fetal proteins or to educate the immune system and favor active immune tolerance upon protein encounter later in life.PMID:37271431 | DOI:10.1016/j.jtha.2023.05.021

Source: Thrombosis and Haemostasis - June 4, 2023 Category: Hematology Authors: Angelina Mimoun Melissa Bou Jaoudeh Sandrine Delignat Victoria Daventure Alejandra Reyes Ruiz Maxime Lecerf Aur élien Azam Remi Noe Ivan Peyron Olivier D Christophe Peter J Lenting Val érie Proulle Jenny McIntosh Amit C Nathwani Jordan D Dimitrov C éci Source Type: research