LncRNA Nron deficiency protects mice from diet-induced adiposity and hepatic steatosis

Obesity, as a worldwide healthcare problem, has attracted more and more attention. Here we identify a long non-coding RNA NRON, which is highly conserved across species, as an important regulator of glucose/lipid metabolism and whole-body energy expenditure. Depletion of Nron leads to metabolic benefits in DIO (diet-induced obesity) mice, including reduced body weight and fat mass, improved insulin sensitivity and serum lipid parameters, attenuated hepatic steatosis and enhanced adipose function.

Source: Metabolism - Clinical and Experimental - June 2, 2023 Category: Biomedical Science Authors: Bing Liu, Yi Zhong, Dandan Huang, Liuye Yang, Pengchao Wang, Liu Yang, Fengxiao Zhang, Xiaoguang Li, Minglu Liang, Kai Huang, Meng Du Source Type: research