Acid-sensing ion channel 1a exacerbates renal ischemia –reperfusion injury through the NF-κB/NLRP3 inflammasome pathway

In conclusion, our study suggests that ASIC1a contributes to renal IRI by affecting the NF-κB/NLRP3 inflammasome pathway. Therefore, ASIC1a may be a potential therapeutic target for AKI.Key messagesKnockout of ASIC1a attenuated renal ischemia-reperfusion injury.ASIC1a promoted the NF- κB pathway and NLRP3 inflammasome activation.Inhibition of the NF- κB mitigated the NLRP3 inflammasome activation induced by ASIC1a.
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research