Salvia officinalis L. Methanolic Extract Reduces Lead and Nicotine-Induced Sperm Quality Degeneration in Male Rats

Chem Biodivers. 2023 May 26:e202300115. doi: 10.1002/cbdv.202300115. Online ahead of print.ABSTRACTThe current study is aimed at evaluating the potential health benefits of Salvia officinalis L. (sage) methanol extract on lead and nicotine hydrogen tartrate-induced sperm quality degeneration in male rats and also identifying some of the non-polar volatile bioactive compounds that might be attributed to the bioactivity of S. officinalis extract using gas chromatography-mass spectrometry (GC-MS). In the study, fifty-four mature male albino rats of about 220 - 250 g [were divided randomly and equally into 9 groups (n=6)]. Sperm quality degeneration was induced through the oral administration of 1.5 g/L of lead acetate in drinking water or peritoneal injection of 0.50 mg/kg (animal weight) nicotine hydrogen tartrate for sixty days. Two doses (200 & 400 mg/kg b.w.) of S. officinalis L. were used. Twelve major compounds were identified. Lead and nicotine toxicity had a great effect on the rats' sperm quality causing a significant (p<0.05) decrease in the quantity of sperm and sperm motility as well as an upsurge in the abnormalities of the sperm and a reduction in the length & diameter of seminiferous tubules and size & weight of sexual organs. The administration of S. officinalis L. methanol extract ameliorates the adversative effects of lead and nicotine.PMID:37236909 | DOI:10.1002/cbdv.202300115
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Source Type: research