Late-Onset Anti-GABAB Receptor Encephalitis: Clinical Characteristics and Outcomes Differing From Early-Onset Patients

This study aims to explore the demographic, clinical characteristics, and prognostic differences between late-onset and early-onset GABABR-E and identify predictors of favorable long-term outcomes.

Methods
This is an observational retrospective study conducted in 19 centers from China. Data from 62 patients with GABABR-E were compared between late-onset (aged 50 years or older) and early-onset (younger than 50 years) groups and between groups with favorable outcomes (modified Rankin scale (mRS) ≤ 2) and poor outcomes (mRS >2). Logistic regression analyses were applied to identify factors affecting long-term outcomes.

Results
Forty-one (66.1%) patients experienced late-onset GABABR-E. A greater proportion of males, a higher mRS score at onset, higher frequencies of ICU admission and tumors, and a higher risk of death were demonstrated in the late-onset group than in the early-onset group. Compared with poor outcomes, patients with favorable outcomes had a younger onset age, a lower mRS score at onset, lower frequencies of ICU admission and tumors, and a greater proportion with immunotherapy maintenance for at least 6 months. On multivariate regression analysis, age at onset (OR, 0.849, 95% CI 0.739–0.974, p = 0.020) and the presence of underlying tumors (OR, 0.095, 95% CI 0.015–0.613, p = 0.013) were associated with poorer long-term outcomes, whereas immunotherapy maintenance for at least 6 months was associated with favorable outcomes (OR, 10.958, 95% CI 1...

Source: Neurology Neuroimmunology and Neuroinflammation - May 25, 2023 Category: Neurology Authors: Sun, T., Zhao, D., Zhang, G., Huang, Y., Guo, J., Jiang, W., Jia, R., Maimaiti, M., Liu, J., Bu, N., Li, Z., Yan, Y., Zhang, X., Sun, C., Zhao, C., Jia, X., Mao, B., Tian, H., Liu, Y., Chen, Z., Fan, Z., Guo, X., Lu, J., Ren, K., Li, H., Guo, J. Tags: Prognosis Research Article Source Type: research