A polyphenol-rich green Mediterranean diet enhances epigenetic regulatory potential: the DIRECT PLUS randomized controlled trial

The capacity of a polyphenol-enriched diet to modulate the epigenome in vivo is partly unknown. Given the beneficial metabolic effects of a Mediterranean (MED) diet enriched in polyphenols and reduced in red/processed meat (green-MED), as previously been proven by the 18-month DIRECT PLUS randomized controlled trial, we analyzed the effects of the green-MED diet on methylome and transcriptome levels to highlight molecular mechanisms underlying the observed metabolic improvements.

Source: Metabolism - Clinical and Experimental - May 24, 2023 Category: Biomedical Science Authors: Anne Hoffmann, Anat Yaskolka Meir, Tobias Hagemann, Paul Czechowski, Luise M üller, Beatrice Engelmann, Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Gal Tsaban, Hila Zelicha, Ehud Rinott, Alon Kaplan, Ilan Shelef, Michael Stumvoll, Matthias Blüher, Limi Source Type: research