Metabolic –related gene signatures for survival prediction and immune cell subtypes associated with prognosis in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (IHCC) originates from intrahepatic epithelium and extrahepatic bile ducts, characterized by cholangiocyte differentiation [1]. IHCC is the second most common primary liver malignancy after hepatocellular carcinoma, accounting for 5 –20% of all primary hepatic malignancies, and incidence of IHCC has increased approximately 14% per year globally [2,3]. Although surgical resection with negative margin is the curative treatment for IHCC if diagnosed at early stage, the 5-year survival rate is about 25–43% due to the high rate of recurrence (> 60%) after surgery [4 –6].
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research