Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of Peripheral Artery Disease

Peripheral artery disease (PAD) causes an ischemic myopathy contributing to patient disability and mortality. Most preclinical models to date use young, healthy rodents with limited translatability to human disease. Although PAD incidence increases with age, and obesity is a common comorbidity, the pathophysiologic association between these risk factors and PAD myopathy is unknown. Using our murine model of PAD, we sought to elucidate the combined effect of age, diet-induced obesity and chronic hindlimb ischemia (HLI) on 1) mobility, 2) muscle contractility, and markers of muscle 3) mitochondrial content and function, 4) oxidative stress and inflammation, 5) proteolysis, and 6) cytoskeletal damage and fibrosis.

Source: Translational Research - May 21, 2023 Category: Research Authors: Emma Fletcher, Dimitrios Miserlis, Kristina Sorokolet, Dylan Wilburn, Cassandra Bradley, Evlampia Papoutsi, Trevor Wilkinson, Andrew Ring, Lucas Ferrer, Gleb Haynatzki, Robert S. Smith, William T Bohannon, Panagiotis Koutakis Source Type: research