Raspberry ketone glucoside suppresses melanin synthesis through IL6/JAK1/STAT3 signal pathway

CONCLUSIONS: RKG showed remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo. Furthermore, RKG could inhibit melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes.PMID:37203852 | DOI:10.26355/eurrev_202305_32336

Source: European Review for Medical and Pharmacological Sciences - May 19, 2023 Category: Drugs & Pharmacology Authors: Q-Q Guo Y-Y Yuan T-W Sun S-J Wu X-H Li H-S Zhao Source Type: research