Comparison of T-cell immune responses to SARS-CoV-2 spike (S) and nucleocapsid (N) protein using an in-house flow-cytometric assay in laboratory employees with and without previously confirmed COVID-19 in South Africa: nationwide cross-sectional study

Conclusions
A significant proportion of South African laboratory employees who were not previously diagnosed with COVID-19 demonstrated T-cell reactivity to SARS-CoV-2 N-proteins and S-proteins. The pre-existing T-cell proliferation responses may be attributable to cross-reactive immune responses to other human coronaviruses, or possibly asymptomatic infection.

Source: Journal of Clinical Pathology - May 18, 2023 Category: Pathology Authors: van Rooyen, C., Brauer, M., Swanepoel, P., van den Berg, S., van der Merwe, C., van der Merwe, M., Green, R., Becker, P. Tags: Open access, COVID-19 Original research Source Type: research