Bone healing around implants placed in subjects with metabolically compromised systemic conditions
AbstractThe aim of this study was to evaluate the bone healing of tight-fit implants placed in the maxilla and mandible of subjects compromised with metabolic syndrome (MS) and type-2 Diabetes Mellitus (T2DM). Eighteen G öttingen minipigs were randomly distributed into three groups: (i) control (normal diet), (ii) MS (cafeteria diet for obesity induction), (iii) T2DM (cafeteria diet for obesity induction + Streptozotocin for T2DM induction). Maxillary and mandibular premolars and molar were extracted. After 8 w eeks of healing, implants with progressive small buttress threads were placed, and allowed to integrate for 6 weeks after which the implant/bone blocks were retrieved for histological processing. Qualitative and quantitative histomorphometric analyses (percentage of bone-to-implant contact, %BIC, and bone area fraction occupancy within implant threads, %BAFO) were performed. The bone healing process around the implant occurred predominantly through interfacial remodeling with subsequent bone apposition. Data as a function of systemic condition yielded significantly higher %BIC and %BAFO val ues for healthy and MS relative to T2DM. Data as a function of maxilla and mandible did not yield significant differences for either %BIC and %BAFO. When considering both factors, healthy and MS subjects had %BIC and %BAFO trend towards higher values in the mandible relative to maxilla, whereas T2DM yielded higher %BIC and %BAFO in the maxilla relative to mandible. All syste...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - Category: Materials Science Authors: Edmara T. P. Bergamo,
Lukasz Witek,
Ilana Ramalho,
Adolfo C. O. Lopes,
Vasudev Vivekanand Nayak,
Estevam A. Bonfante,
Nick Tovar,
Andrea Torroni,
Paulo G. Coelho Tags: RESEARCH ARTICLE Source Type: research
More News: Diabetes | Diabetes Mellitus | Diabetes Type 2 | Diets | Eating Disorders & Weight Management | Endocrinology | Materials Science | Metabolic Syndrome | Nutrition | Obesity | Study