Elevated plasma p-tau181 levels unrelated to Alzheimers disease pathology in amyotrophic lateral sclerosis

Conclusions Plasma p-tau181 is elevated in patients with ALS, independently from CSF levels, and is firmly associated with LMN dysfunction. The finding indicates that p-tau181 of putative peripheral origin might represent a confounding factor in using plasma p-tau181 for AD pathology screening, which deserves further investigation.

http://jnnp.bmj.com/cgi/content/short/94/6/428?rss=1

Source: Journal of Neurology, Neurosurgery and Psychiatry - May 15, 2023 Category: Neurosurgery Authors: Vacchiano, V., Mastrangelo, A., Zenesini, C., Baiardi, S., Avoni, P., Polischi, B., Capellari, S., Salvi, F., Liguori, R., Parchi, P., on behalf of the BoReALS group, Cinelli, Stasi, Plasmati, Pastorelli, Quarta, Milletti, Nasca, Rizzi, Santoro, Valeriani Tags: Editor's choice Neurodegeneration Source Type: research