Effect of megaloblastic anemia on hemoglobin A < sub > 2 < /sub > and diagnosis of β-thalassemia trait

CONCLUSIONS: Megaloblastic anemia can lead to false-positive diagnosis of β-thalassemia trait on HPLC. Repeat HPLC should be done after adequate supplementation of vitamin B12 and folic acid in cases of megaloblastic anemia with raised HbA2. Red cell parameters are not helpful to suspect β-thalassemia trait in presence of megaloblastic anemia. However, HbA2% on HPLC can be a useful parameter to suspect or exclude β-thalassemia trait in cases of megaloblastic anemia.PMID:37077076 | DOI:10.4103/ijpm.ijpm_233_21

Source: Indian Journal of Pathology and Microbiology - April 20, 2023 Category: Pathology Authors: Sulagna Sahoo Nageswar Sahu Palash Das Urmila Senapati Source Type: research