Reactivation of Parvovirus B19 Infection: An Uncommon Trigger of Macrophage Activation Syndrome in Adult-Onset Still's Disease

Cureus. 2023 Apr 6;15(4):e37231. doi: 10.7759/cureus.37231. eCollection 2023 Apr.ABSTRACTA 40-year-old woman presented with four weeks of intermittent high-grade fever, cough, and joint pain, and two weeks of a generalized rash. She was found to have adult-onset Still's disease (AOSD) and rapidly developed macrophage activation syndrome (MAS) on the second day of admission. Among infectious etiologies, Epstein-Barr virus and members of the herpes virus family are common triggers of MAS. However, our patient was found to have reactivation/recurrence of parvovirus B19 infection as the cause; this is an uncommon trigger reported infrequently in the medical literature. Despite intensive treatment, the patient passed away.PMID:37162784 | PMC:PMC10164221 | DOI:10.7759/cureus.37231
Source: Herpes - Category: Infectious Diseases Authors: Source Type: research