Chitinase 3-like 1 induces cancer cell migration in solitary fibrous tumors

In this study, we found that chitinase 3-like 1 (CHI3L1), which induces cancer cell migration, was upregulated in NIH-3T3 cells that were transfected with the NAB2-STAT6 fusion gene. Moreover, the expression levels of the migration markers MMP2 and MMP9 were increased and the p-Akt level was also upregulated. In addition, it was observed that when CHI3L1 siRNA was transfected into NAB2-STAT6-transfected cells, cell migration and proliferation were reduced. Therefore, this study demonstrated that CHI3L1 activates Akt signaling to induce cell migration.PMID:37121124 | DOI:10.1016/j.bbrc.2023.04.057
Source: Cell Research - Category: Cytology Authors: Source Type: research