Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma

Epigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted delivery of CRISPR-activation (CRISPRa) systems makes it possible to expl...

Source: Clinical Epigenetics - April 29, 2023 Category: Research Authors: Agustin Sgro, Joseph Cursons, Charlene Waryah, Eleanor A. Woodward, Momeneh Foroutan, Ruqian Lyu, George C. T. Yeoh, Peter J. Leedman and Pilar Blancafort Tags: Research Source Type: research