Matrix stiffness aggravates osteoarthritis progression through h3k27me3 demethylation induced by mitochondrial damage

Purpose: Chondrocytes can sense changes in matrix stiffness and affect energy metabolism through mitochondria. Mechanically associated changes in mitochondria are closely involved in osteoarthritis (OA) progression. In addition to their well-known roles in energy metabolism, mitochondria communicate with the nucleus, reprogramming transcriptional profiles to adapt to mechanical stimulation, which is essential for organismal health. Emerging studies have documented that mitochondrial-to nuclear communication via metabolites causes various epigenetic changes, affecting disease development and progression.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research