Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation

In conclusion, cell-autonomous gp130 signaling alters T cell differentiation. Although gp130 signaling is not sufficient for TH17 cell differentiation, it still promotes accumulation of activated T cells in the lung that cause tissue inflammation.PMID:37058116 | DOI:10.4049/jimmunol.2200461

Source: Journal of Immunology - April 14, 2023 Category: Allergy & Immunology Authors: Lisa Charlotte Heinig Emily Valentina Madelaine Huth Karsten Yan Neele Schumacher Mikolaj Nawrocki Niels Christian Lory Peter Bradtke Tabea Bertram Guido Rattay Joanna Schmid Samuel Huber Thorsten Wiech Dirk Schmidt-Arras Stefan Rose-John Hans-Willi Mittr Source Type: research