Curcumin ‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

Most studies reported that the inflammatory cells are found in the wound area of the control as well as all various treatment groups, on day 3 posttreatment. But interestingly, unlike control groups, the curcumin (CUR)-involved systems showed the beginning of cell proliferation and migration, reepithelization, granulation generation, and collagen deposition from the first days of treatment. So, it is concluded that besides the inflammation phase, CUR plays a critical role also in other wound healing phases. AbstractDespite numerous advantages, curcumin's (CUR) low solubility and low bioavailability limit its employment as a free drug. CUR-incorporated nanoformulation enhances the bioavailability and angiogenesis, collagen deposition, fibroblast proliferation, reepithelization, collagen synthesis, neovascularization, and granulation tissue formation in different wounds. Designing nanoformulations with controlled-release properties ensure the presence of CUR in the defective area during treatment. Different nanoformulations encompassing nanofibers, nanoparticles (NPs), nanospray, nanoemulsion, nanosuspension, nanoliposome, nanovesicle, and nanomicelle were described in the present study comprehensively. Moreover, for some other systems which contain nano-CUR or CUR nanoformulations, including some nanofibers, films, composites, scaffolds, gel, and hydrogels seems the CUR-loaded NPs incorporation has better control of the sustained release, and thereby, the presence of CUR until...
Source: BioFactors - Category: Biochemistry Authors: Tags: REVIEW ARTICLE Source Type: research