Clinical Manifestation of AGE-RAGE Axis in Neurodegenerative and Cognitive Impairment Disorders

Drug Res (Stuttg) DOI: 10.1055/a-2004-3591The receptor of Advanced Glycation Endproducts (RAGE) and Advanced Glycation
Endproducts (AGE) have multiple functions in our body and their restraint are
being observed in neurodegenerative and memory impairment disorders. The review
of different pathways allows an understanding of the probable mechanism of
neurodegeneration and memory impairment involving RAGE and AGE. Commonly we
observe AGE accumulation in neural cells and tissues but the extent of
accumulation increases with the presence of memory impairment disorder. The
presence of AGEs can also be seen in morbid accumulation, pathological
structures in the form of amyloid clots, and nervous fibrillary tangles in
Alzheimer’s Disease (AD) and memory impairment disease.Many neuropathological and biochemical aspects of AD are explained by AGEs,
including widespread protein crosslinking, glial activation of oxidative stress,
and neuronal cell death. Oxidative stress is due to different reasons and
glycation end products set in motion and form or define various actions which
are normally due to AGE changes in a pathogenic cascade. By regulating the
transit of ß-amyloid in and out of the brain or altering inflammatory
pathways, AGE and it’s ensnare receptor such as soluble RAGE may
function as blockage or shield AD develo...

Source: Drug Research - April 11, 2023 Category: Drugs & Pharmacology Authors: Naz, Sabreena Mahmood, Tarique Gupta, Ramesh Siddiqui, Mohammed Haris Ahsan, Farogh Ansari, Vaseem Ahamad Shamim, Arshiya Rizvi, Ali Abbas Tags: Review Source Type: research