Alemtuzumab treatment exemplifies discordant immune effects of blood and cerebrospinal fluid in multiple sclerosis

Immune responses in the central nervous system (CNS) are highly compartmentalized and cerebrospinal fluid (CSF) in particular often reflects CNS pathology better than peripheral blood. While CSF leukocytes are known to be distinct from blood, the immediate effects of peripheral leukocyte depletion on CSF leukocytes have not been studied in humans.

Source: Journal of Neuroimmunology - April 11, 2023 Category: Allergy & Immunology Authors: Louisa M üller-Miny, Michael Heming, Tobias Lautwein, Tobias Ruck, I-Na Lu, Heinz Wiendl, Gerd Meyer Zu Hörste Source Type: research