Do Histologically Aggressive Subtypes of Papillary Thyroid Microcarcinoma have Worse Clinical Outcome than Non-Aggressive Papillary Thyroid Microcarcinoma Subtypes? A Multicenter Cohort Study
In this study, we intended to determine the difference in clinical
outcomes between patients with aggressive and non-aggressive PTMC subtypes. In
this multicenter cohort study, the computer-recorded clinical and
histopathological data of patients who underwent thyroid surgery between January
2000 - January 2021 in 9 referral centers and were diagnosed as PTMC were
analyzed. A total of 1585 patients [female 1340 (84.5%), male 245
(15.5%), mean age 47.9±11.63 years), with a mean follow-up time
of 66.55±37.16 months], were included in the study. Ninety-eight cases
were diagnosed as aggressive and 1487 as non-aggressive subtypes.
Persistent/recurrent disease was observed in 33 (33.7% )and 41
(2.8%) patients with aggressive and non-aggressive subtypes
(p<0.001). Diseases-free survival rates were markedly lower in patients
with aggressive than in those with non-aggressive PTMC subtypes (66.3 vs.
94.8%, log-rank p<0.001). Moreover, in multivariate analysis,
aggressive histology was an independent predictor of
persistent/recurrent disease, after controlling for other contributing
factors (HR 5.78, 95% CI 3.32–10, p<0.001). Patients
with aggressive PTMC subtypes had higher rates of incomplete biochemical and
structural response than patients with non-aggressive subtypes as well
(p<0...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Zuhur, Sayid Shafi Aggul, Hunkar Avci, Ugur Erol, Selvinaz Tuna, Mazhar M üslüm Uysal, Serhat Akbaba, Gulhan Kilin ç, Faruk Catak, Merve Tekin, Sakin Bilen, Ogun Irem Öztürk, Beyza Olcay Erden, Ecem Bilgehan Elbuken, Gulsah Yavuz, Halise Cinar Kadiog Tags: Original Article: Endocrine Care Source Type: research
More News: Cancer & Oncology | Carcinoma | Computers | Endocrinology | Hormones | Study | Thyroid | Thyroid Cancer