Cytokines in primary headache disorders: a systematic review and meta-analysis

ConclusionsThe higher levels of the proinflammatory cytokines IL-6, IL-8 and TNF- α in migraine compared to controls, and IL-1β during the ictal stage, suggest a role for inflammation in the pathophysiology of migraine, however prospective studies are required to confirm causality and investigate the mechanisms for the increase in cytokine levels identified. Cytokines may also have a role in tension-type headache. Due a lack of data, no conclusions can be made regarding cluster headache or NDPH.

Source: The Journal of Headache and Pain - April 4, 2023 Category: Neurology Source Type: research