Suppression of mTOR expression by siRNA leads to cell cycle arrest and apoptosis induction in MDA-MB-231 breast cancer cells

CONCLUSION: With these results, we can conclude that mTOR-siRNA exerts direct 'anti-breast cancer' activity propagated by the S6K-GSK-3β- caspase 3 mediated apoptosis and by inducing cell cycle arrest.PMID:36999418 | DOI:10.2174/1566523223666230329085606

Source: Current Gene Therapy - March 31, 2023 Category: Genetics & Stem Cells Authors: Roja Sahu Shivesh Jha Shakti Pattanayak Source Type: research